Epileptic seizures were caused by Alumina cream in the rabbits with experimental chronic local cerebral anaphylaxis by repeating injections of diluted cow serum with phosphatide as antigen every 4 days for a long time, and in the normal. The results were as follows: 1) The epileptic seizures occurred earlier in the chronic cerebral local anaphylactic rabbits than in the normal by infusion of 2% Alumina cream into the cisterna magna. 2) The injection of Alumina cream into the brain substance did not show any difference between the both groups. 3) When the Alumina cream disk was put on the surface of the brain, a distinctly higher frequency of seizures was observed in the chronic cerebral local anaphylactic rabbits. 4) By the Alumina cream disk the nerve cells showed a marked degeneration and a tendency of atrophy, but there was no difinite difference between the both groups. 5) In short, by the experiment with Alumina cream, it was cleared that, the chronic cerebral local anaphylactic rabbits were ready to start the epileptic seizure more easily than the normal and seemed to have an epileptic arrangement.