The ketoenolic granules were investigated in the motor cortex and the results were as follows: 1. No change was observed at the preconvulsive stadium. 2. The granules in the nerve cells, especially in the Betz's giant pyramidal cells decreased or disappeared and those in the Nissl's gray substance rather increased at the acme and the postconvulsive stadium. This fact suggested the ketoenolic substance moved from the ganglion-cells to the Nissl's gray substance or to the nerve fibers at the moment of such great consumption of energy as convulsion. And this change recovered gradually to the normal as time elapsed, which was similar to the above-stated changes of the water content in the brain. It was interesting that this change was most striking in the Betz's cells which were considered to have very close relation to convulsion.