Journal of Okayama Medical Association
Published by Okayama Medical Association

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分裂病の研究補遺 第3編 インシュリン治療による赤血球性状の変化

Hoaki, Akitaka
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The auther took observation to find some clue for pathogenesis of schizophrenia, on certain physical natures of erythrocytes. attacking the most general somatic aspect above all, on their diameter, specific gravity, number, hematocrit value, volume, thickness, spheric index (spread of erythrocytes), inverse spheric index (swell or dilation of erythrocytes), as well as their resistance against NaCl solution. In Ist chapter, the auther took investigation to know whether the erythroeytes of schizophrenics had specific natures. compared to those of normal subjects or non-schizophrenics; moreover examined if there existed any difference even for various clinical types or states of schizophrenics. In 2nd chapter, the auther investigated about changes in the physical properties of schizophrenic erythrocytes by electric shock therapy, besides if they had certain special differences from those of depression and neurosis, and examined the changes between acute or chronic progressive schizophrenic types, by comparative study. In 3rd chapter, the auther examined as to those effects occurred by insulin shock therapy on the physical properties of schizophrenic erythrocytes. The results of the investigation were summarized as follows;1st chapter. 1) Examined; normal, 20 cases; non-schizophrenics, 22; schizophrenics, 60; respectively, male and female were same in number. 2) Schizophrenic erythrocytes are discovered to have a large diameter, rather thin, and small in volume. Their spheric index proved below 0.23; their inverse spheric index, above 40. The specific gravity of the total blood and the blood plasma proved heavy, but that of erythrocytes suffered no changes. As to resistance, they proved an incrcase in the width of it due to the shift of the maximum resistance, which brought about an increase in their resistance. 3) The volume, thickness, spheric index, and inverse spheric index etc. of schizophrenic erythrocytes, compared to those of non-schizophrenics, indicated specific changes. 4) Erythrocytes in excitatory state of schizophrenic is larger and flatter than those in stuporous; as special features in stuporous state, schizophrenic erythrocytes proved light in their gravity, while numerous. 5) While becomes remission, the diameter of erythrocytes reduces compared to worse time: thickness, spheric index, inverse spheric index, resistance, and number, all come back to their former normal state, but on the contrary, their specific gravity and volume indicate even a rise. 2nd chapter. 1) The physical changes taking place in erythrocytes in those three periods, i.e., immediately before as well as after, 90 minutes after E. C. T., were duly laid under observation, employing 26 schizophrenic cases, 12 non-schizophrenic; summing up, 38 cases. 2) Such as the erythrocytes diameter, the specific gravity of total blood as well as blood plasma, hematocrit value, volume, thickness of erythrocytes. each showed certain degree of increase by E. C. T.; after 90 minutes, it relapsed to the direction of before E. C. T., and the specifie gravity of erythrocytes decreased immediately after E. C. T., contrary to the changes of total blood or blood plasma, and then it became heavier again after 90 minutes. Both spheric index and inverse spheric index altered their course toward increase by E. C. T., which recovered as before, after 90 minutes. 3) Between schizophrenics and non-schizophrenics, essential differences are as to those changes in the specific gravity of erythrocytes and in their number, the specific gravity in schizophrenics being slow to regain its self-same state, while their number in non-schizophrenics though regained normal self, it keeped on abating trend in schizophrenics. The resistance of schizophrenic erythrocytes was weakend by E. C. T. and recovered afterwards. The width of resistance, though enlarged itself, after a while underwent certain shrinkage.