Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

非機能性膵内分泌腫瘍の1切除例

Tsunemitsu, Yosuke
Inagaki, Masaru
Hamano, Ryosuke
Nishie, Manabu
Tokunaga, Naoyuki
Otsuka, Shinya
Osaki, Toshihide
Iwagaki, Hiromi
Thumnail 120_169.pdf 6.25 MB
Abstract
We report a rare case of a very large nonfunctioning endocrine tumor of the pancreas without malignant histological features. A 63-year-old woman referred for appetite loss and general fatigue was found to have a tumor in the pancreas head. Computed tomography demonstrated a well-defined pancreatic tumor 45mm in diameter with hypervascular staining in the pancreas head. Angiography showed a hypervascular tumor of the pancreas head and a dilatation of the anterior superior and posterior superior pancreaticoduodenal arteries. The preoperative diagnosis was an endocrine tumor of the pancreas, with undeniable malignancy. Pylorus-preserving pancreaticoduodenectomy was performed. The histopathological diagnosis was a benign nonfunctioning endocrine tumor of the pancreas based on immunohistochemical staining for Chromogranin A, Synaptophysin, and NSE, but not for hormones. The tumor revealed a low labeling index (<2.0%) of Ki-67 indicating its benign character. No tumor recurrence has been identified in the 18 months since surgery.
Keywords
非機能性(nonfunctioning)
膵内分泌腫瘍(endocrine tumor of the pancreas)
膵島細胞腫瘍(islet cell tumor)
Note
症例報告
ISSN
00301558
NCID
AN00032489