Choroidal arteriole changes after experimental destruction of the outer layer of the retina

The purpose of the present study is to clarify the changes of choroidal circulation developing in the selective injuries of the outer layer of the retina. One, 2, 3 weeks and 3 months after intravenous administration of Monoiodoacetic acid in the rabbits, choroidal vessels were observed using indocyanine green angiography (ICG). The diameter of retinal arterioles decreased significantly at 3 weeks and 3 months after the treatment and hypofluorescence in the background was observed at 3 months. Histological examination revealed significant decrease in choriocapillaris at 3 weeks, a thickening of the endothelial cytoplasma and a disappearance of fenestration in choriocapillaris after 3 months. These histological findings were considered to be a cause of hypofluorescence of background in ICG. The results suggest that the selective damage of the outer layer of the retina induce changes in the choroidal circulation.

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