Journal of Okayama Medical Association
Published by Okayama Medical Association

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骨髄異形成症候群における骨髄細胞周期に関する研究

Tanimizu, Masakuni
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Abstract
Bone marrow cell cycle analysis was performed on 23 patients with myelodysplastic syndrome (MDS)[12 with refractory anemia(RA), two with RA with ringed sideroblasts(RARS), three with RA with excess blasts(RAEB), six with RAEB in transformation(RAEBt)], and 14 normal volunteers. Cells were stained with propidium iodide and analyzed by flow-cytometry. Patients with RA and RARS (low-risk MDS) showed higher rates of S-phase (21.2±4.9%) and patients with RAEB and RAEBt (high-risk MDS) showed lower rates of S-phase (9.9±5.9%) compared with normal controls (15.2±3.1%). Although the rate of S-phase decreased with disease progression, it was normalized with complete remission. An intermediate correlation (r=0.64, p<0.01) existed between the rate of S-phase and the percentage of erythroblasts in MDS. The rate of S-phase clearly reflects the severity of MDS. The high rate of S-phase in low risk MDS was concidered to be due to erythroid hyperplasia with ineffective hematopoiesis.
Keywords
Myelodysplastic syndrome
Flowcytometry
Cell cycle analysis
Erythroid hyperplasia
Ineffective hematopoiesis
Note
原著
ISSN
0030-1558
NCID
AN00032489