Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

血清中カルバマゼピン濃度に及ぼすフェニトインおよびバルプロ酸併用の影響

Kishima, Miyuki
Yao, Kazuhisa
Yasuhara, Kanako
Suemaru, Katsuya
Furuno, Katsushi
Oishi, Ryozo
Gomita, Yutaka
Ohtahara, Shunsuke
106_757.pdf 267 KB
Abstract
To clarify the pharmacokinetic interaction in poly-therapy for epilepsy, the serum concentration of carbamazepine (CZB) was measured in epileptic patients to whom CBZ had been prescribed chronically with or without phenytoin (PHT) and sodium valproate (VPA). The serum CBZ concentrations increased with increasing doses of CBZ, but increased less at higher doses. Chiliren (<12 yrs) showed lower serum CBZ concentrations than patients 12 years old and older. The L/D ratios (L : CBZ level, D : dose/body weight) were significantly decreased by the combined treatment with PHT and VPA in a dose-dependent manner, probably due to an induction of metabolizing enzyme. These findings suggest that especially in the case of change of the drug therapy from mono-therapy to mono therapy, careful monitoring of serum concentration is necessary.
Keywords
カルバマゼピン
フェニトイン
バルプロ酸
血清中濃度
薬物相互作用
Note
原著
ISSN
0030-1558
NCID
AN00032489