Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

気管支喘息の発症に関する研究 第2編 喘息患者におけるサイトメガロウイルス抗原によるリンパ球幼若化反応の検討

Okamoto, Makoto
106_743.pdf 371 KB
Abstract
The possible role of virus infection in the occurrence and attack of asthma was examined by measuring the lymphocyte transformation test to CMV in 44 asthmatic and 14 healthy subjects and analyzed their relation to the clinical parameters. CMV-induced lymphocyte reactivity (CMV-LR) in adult asthmatics was significantly higher than that in the healthy controls. A positive correlation was observed between CMV-LR titer and CMV-complement fixation (CMV-CF) antibody titers (r=0.35). In adult asthmatics, the CMV-LR in the high IgE titer (100U/ml≦) group was significantly higher than that in the low IgE titer (<100U/ml) group. These findings suggest that CMV is an important factor in the pathogenesis of adult asthma mediated by lymphocytes and probably IgE, although the precise mechanism in still unknown.
Keywords
bronchial asthma
viral infection
Cytomegalovirus
IgE
CMV-LTT
Note
原著
ISSN
0030-1558
NCID
AN00032489