Heredity has long been suspected to play an important role in the occurrence of bronchial asthma. Recently familial and twin sibling studies demonstrated the role of genetic factors in asthma. Therefore, we measured HLA antigens of 53 asthmatics and analyzed the relationship to clinical parameters to elucidate the role of HLA in the occurrence of bronchial asthma. Four major findings were obtained. 1) Study of the HLA system in asthmatics showed a significantly higher frequency of DR53 and DQ3 and lower frequency of DQ1, DQ6 (1) and DQ7(3). This suggests that DR molecules demonstrate positive associations and DQ molecules negative associations with bronchial asthma. 2) DQ1 was associated with IgE production in asthmatics. 3) B39(16) positively associated with RAST score of Candida. 4) The study of late onset asthmatics, intractable asthmatics and the high responder group of in vitro lymphocyte reaction to Candida allergen showed a cooperatively and significantly higher frequency of DR53(P<0.05). These findings suggest that DR53 has a positive association with onset of late onset intractable asthma.
late onset intractable asthma