Journal of Okayama Medical Association
Published by Okayama Medical Association

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Mechanism of immunotherapy related to the production of antigen specific IgG subclass antibodies and leukotrienes in bronchial asthmatics

Katagi, Sachie
106_539.pdf 457 KB
Published Date
1994
Abstract
To clarify the mechanism of immunotherapy in bronchial asthma, the level of mite specific IgG subclass asntibodies (total IgG, IgG(1), IgG(4)) and the production of leukotrienes (LTB(4), LTC(4)) released from leukocytes were examined. Eighteen mite-sensitive asthmatic patiens who received immunotherapy with house dust extract for 1 year were dividel into two groups, the responsive patients and non-responsive patients. Before treatment and 1 year after treatment, the levels of mite specific serum IgG subclass antibodies were measured by enzyme-linked immunosorbent assay (ELISA) and the levels of LTs were measured by high performance liquid chromatography (HPLC). In the responsive group, the level of mite specific serum IgG(4) antibody was significantly increased (p<0.05), and the level of mite specific serum total IgG and IgG(1) antibody was decreased. The release of LTB(4) and LTC(4) from leukocytes stimulated by mite antigen was significantly decreased (p<0.05,p<0.05). These results indicate that increases in the antigen specific IgG(4) and the inhibiton of chemical madiators play important roles in the mechanism of immunotherapy.
Keywords
bronchial asthma
immunotherapy
IgG subclass antibodies
leukotrienes
Note
原著
ISSN
0030-1558
NCID
AN00032489