Journal of Okayama Medical Association
Published by Okayama Medical Association

<Availability>
Full-text articles are available 3 years after publication.

心筋酸素需要増加時および反応性充血の冠動脈トーヌスに対するKATP channelの影響

Kobayashi, Hiroo
Thumnail 106_451.pdf 549 KB
Abstract
To evaluate the role of the KATP channel in regulating coronary tonus in response to increases in myocardial oxygen conaumption, and reactive hypermia following ischemia, coronary blood flow was measured with glibenclamide, a KATP channel blocker (50μmol/l ic.) and pinacidil, a KATP channel opener, (10μmol/l ic.) The following interventions were applied in the control and during intracoronary infusions of glibenclamide alone or glibenclamide plus pinacidil : 1) intravenous infusion of isoproternol (0.125μg/kg/min), 2) aortic constriction to raise the mean aortic pressure by 30%. The slope of the regression line of coronary conductance of mycardial oxygen consumption was significantly decreased with glibenclamide (p<0.05), but returned to the baseline with pinacidil, both during isoproterenol infunsion and aortic constriction. Reactive hyperemia following a 20-sec coronary occlusion was also attennuated with glibenclamide and recovered with pinacidil. These findings suggest that the KATP channel regulates coronary artery tonus during the increase in myocardial oxygen consumption and transient myocardial ischemia.
Keywords
KATP channel
glibenclamide
myocardial oxygen consumption
coronary conductance
Note
原著
ISSN
0030-1558
NCID
AN00032489