Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

パーキンソン病における局所脳血流量の定量的検討―特に臨床病期分類および精神症状との関連について―

Kitamura, Yoshihiro
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Abstract
Regional cerebral blood flow (rCBF) was evaluated in 63 patients with Parkinson's disease (PD) by single-photon emission computed tomography (SPECT) using N-isopropyl-p-(123)I-iodoamphetamine ((123)I-IMP) as a tracer. Evaluation of the SPECT images was performed in accordance with the rCBF quantification method using a microsphere model. Patients in stage Ⅳ demonstrated significanlty lower rCBF than those in stage Ⅱ at the frontal, tempo-ral, parietal, occipital regions and in the thalamus and celebellum. Subjects with mental sumptoms demonstrated decreased rCBF in every region in the brain. The present study indicates that clinical exacerbation and manifestation of dementia and other psychiatric aymptoms in Parkinson's disease are associated with decreased blood flow in various brain regions.
Keywords
Parkinson病
SPECT
臨床病期分類
精神症状
Note
原著
ISSN
0030-1558
NCID
AN00032489