Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

難治性喘息の治療に関する研究 第1編 モルモット喘息モデルにおける細胞反応型アルルギーに対する柴朴湯の効果

Okamoto, Shoichi
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Abstract
Saiboku-to seems to be a useful drug in the teatment of intractable asthmatics. The pharmacological effect of Saiboku-to was examined in an experimental model of bronchial asthma with cell-mediated allergy in guinea pigs. The fundings revealed that Saiboku-to inhibited the late asthmatic response. It suppressed the lymphocyte blastogensis by ascaris antigen and eosinophil infiltration into BALF and peribronchial tissue. Moreover, Saiboku-to lowered the levls of LTB4 and LTC4 in the cardiac blood, but not the antigen-specific IgG subclass. These findings suggest that the inhibitory effect of Saiboku-to on the late asthmatic response is caused by the suppression of cell-mediated allergy.
Keywords
Saiboku-to
cell-mediated allergy
actively sensitized model
lymphocyte
leukotrienes
Note
原著
ISSN
0030-1558
NCID
AN00032489