Journal of Okayama Medical Association
Published by Okayama Medical Association

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歯肉炎自然発症ラットの歯肉炎発症におけるフリーラジカルの関与に関する研究

Satoh, Kazuyoshi
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Abstract
Free radicals, superoxide dismutase activity and lipid peroxides in the gingiva of Dental University (ODU) plaque-susceptible (Sus) rats were estimated at the ages of 1,2,3,4,5,7 and 8 months, and were compared with those of control Wistar-kyoto rats. Low levels of hydroxyl radicals were noted in the anterior and posterior gingiva of ODU Sus rats at 2 and 5 month, but significantly increased in the anterior gingiva at 4 and 7 months and in the anterior and posterior gingiva at 7 and 8 months, compared to those of control rats. Levels of carbon centered radicals were significantly higher in the anterior gingiva at 2 months and in both the anterior and posterior gingiva at 3 months. Superoxide dismutase activities were accelerated significantly at 2,4 and 5 months, and then were reduced at 8 months in the anterior gingiva. Otherwise, they were at low levels in the posterior gingiva at 1 and 2 months, were accelerated at 3 and 4 months, and reduced again at 7 and 8 months. Thiobarbituric acid reactive substances decreased transitorily at 7 months in both the anterior and posterior. These experimental results suggest that free radicals may be related to the pathogenesis and development of gingivitis in plaque susceptible ODU Sus rats.
Keywords
歯肉炎自然発症ラット
フリーラジカル
活性酸素
過酸化脂質
スーパーオキシドジムスターゼ活性
ISSN
0030-1558
NCID
AN00032489