Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

慢性経口投与による ACE 阻害剤の虚血心筋保護効果

Naitoh, Minoru
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Abstract
The protective effect of angiotensin converting enzyme inhibitors (ACEI) on myocardial ischemia and reperfusion injury was estimated in the isolated working rat heart. Male Wistar rats were divided into four groups and reared for 6 weeks : fed without ACEI (Group A), fed with Captopril 30mg/kg/day (Group B), fed with Captopril 60mg/kg/day (Group C) and fed with Enalapril 20mg/kg/day (Group D). Isolated perfused rat hearts were ischemic for 20min at 37℃ and were reperfused for 30min at 37℃. Addition of ACEI preserved cardiac output, prevented increase of coronary resistance and release of cardiac enzyme (CPK) in Group B,C,D hearts compared with Group A. These findings suggest that ACEI can protect the myocardium from ischemia and reperfusion injury by pretreatment.
Keywords
captopril
enalapril
心筋保護
再灌流障害
isolated rat heart
ISSN
0030-1558
NCID
AN00032489