Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

組織培養法を用いた肺癌の細胞生物学並びに治療に関する研究 第2編 肺小細胞癌細胞株の樹立とその生物学的特徴

Kishimoto, Nobuyasu
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Abstract
Five small cell lung cancer (SCLC) cell lines in culture were established and designated as SBC-1, 2, 3, 4 and 5. SBC-1, 2, 4 and 5 were derived from tumors of intermediate cell histology, and SBC-3 was from a tumor of oat cell histology. All the cell lines represented a characteristic cytomorphology of SCLC when examined by papanicolaou staining and by electron microscopy. Their biological characterstics such as doubling time, clonogenic activity, heterotransplantability in nude mice, and capacity of hormone production in culture revealed that each cell line had a distinct biological feature. The SCLC cell lines reported here would be useful as a tool for cellular pharmacology of new drugs and drug resistance.
Keywords
small cell lung cancer
cell line
characterization
Note
原著
ISSN
0030-1558
NCID
AN00032489