Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

鉄代謝におけるマクロファージのトランスフェリンレセプターに関する研究 第2編 鉄過剰及び鉄欠乏状態における肺胞マクロファージのトランスフェリンレセプターに関する検討

Inada, Toshio
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Transferrin receptors (TfR) are involved in the first step of iron uptake into cells. To clarify the changes in TfR under various conditions, radiobinding assay of (125)I-labeled iron-saturated transferrin was performed in alveolar macrophages from 2 patients with idiopathic hemo-chromatosis and iron-overloaded or iron-deficient guinea pigs. Patients with idiopathic hemochromatosis showed a reduction in the Fe-TfR count on alveolar macrophages (5.0×10(4)/cell) as compared to that in healthy individuals (19.88±8.19×10(4)/cell). Concerning the Fe-TfR binding constant, no differnce was observed between patients with idiopathic hemochromatosis and healthy controls. The Fe-TfR count on alveolar macrophages was significantly lower in iron-overloaded guined pigs than in normal cntrols. The count was significantly elevated in iron-deficient guinea pigs. Concerning the Fe-TfR binding constant, none of the iron-overloaded and iron-deficient groups showed any significant difference from the normal controls. These findings suggest that experimentally-induced iron overload and iron deficiency may be autoregulated by intracellular iron levels.
Transferrin receptor
Iron overloaded
Iron depleted Alveolar macrophage