Foci of tissue sponginess and necrosis in the cerebral cortex and the subcortical white matter were studied histopathologically in three cases of Neuro-Behçet's disease. The following results were obtained: Lesions in the cerebral cortex and the subcortical white matter were less severe than those in the brain stem. Though recent and older foci coexisted, glial scar foci were rare. Necrotic foci in the cerebral cortex and the subcortical white matter were vascular in origin. Foci were more numerous in the cerebral cortex than in the subcortical white matter. Foci were relatively numerous in the temporal lobe, especially in the hippocampus (Case 2), and were not so numerous in the frontal lobe. Mental symptoms such as hypospontaneity, blunted affect, euphoria, distrubance of immediate and recent memory, forced laughing and crying and bradyphrenia are attributable to brain stem lesions, but some cases of Neuro-Behçet's disease with numerous necrotic foci in the hippocampus and adjacent structures are believed to have hippocampal amnesia superimosed on brain stem symptoms.
microspongy state of the cerebral cortex
subcortical white matter change