Journal of Okayama Medical Association
Published by Okayama Medical Association

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気管支喘息の血小板機能に関する研究 第2編 喘息患者血小板の12-HETE 産生能とリンパ球機能に及ぼす影響に関する検討

Sunami, Koji
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Abstract
To clarify the role of platelets in the pathogenesis of bronchial asthma, the production of 12-hydroxyeicosatetraenoic acid(12HETE) from platelets of asthmatics was examined by high performance liquid chromatography(HPLC). The effect of platelets on lymphocyte function was also studied by lymphocyte blastogenesis. The results were as follows : 1) The production of 12HETE from platelets of asthmatics were significantly higher than that of normal subjects(p<0.01). 2) Blastogenesis of lymphocytes was significantly suppressed by addition of platelets(p<0.05). 3) Blastogenesis of lymphocytes was significantly suppressed by addition of more than 12.5ng/ml of 12HETE, 10ng/ml of transforming growth factorβ(TGE-β) or 50ng/ml of serotonin. These results suggest that platelets play an important role in the pathogenesis of asthmatic responses mediated by activated lymphocytes.
Keywords
platelet
bronchial asthma
12HETE
lymphocyte
Note
原著
ISSN
0030-1558
NCID
AN00032489