Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

気管支喘息の血小板機能に関する研究 第1編 喘息患者血小板の形態変化とセロトニン遊離能の検討

Sunami, Koji
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Abstract
To calrify the role of platelets at the site of allergic reaction, ultrastructural observation, measurement of plasma serotonin levels and serotonin-releasability of platelets after various stimuli were studied in 29 asthmatics and 6 normal controls. The results were as follows : 1) Plasma serotonin levels were higher during the attack stage than non-attack stage in asthmatics. 2) Morphological changes and the aggregation of platelets were observed by scanning electron microscopy after stimulation with platelet activating factor(PAF), CaI, anti-IgE and anti-IgG. 3)The serotonin-releasability of platelets stimulated by CaI was significantly decreased in severe asthmatics, compared with mild asthmatics and normal subjects(p<0.05). However, there were no significant differences between steroid dependent and non-steroid dependent intractable asthmatics in severe asthma. 4) The releasability of serotonin was decreased in most cases during asthmatic attack and was suppressed by aminophyllin. 5) The serotonin-releasability of platelets stimulated by anti-IgG of Candida antigen was remarkably enhanced aftre incubation with serum, although releasability was not increased with heart-treated serum. These results suggest that platelets play an important role in bronchoconstriction induced by various immunological reactions involved with complement activation in the pathogenesis of bronchial asthma.
Keywords
platelet
serotonin
bronchial asthma
Note
原著
ISSN
0030-1558
NCID
AN00032489