Journal of Okayama Medical Association
Published by Okayama Medical Association

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Studies on the lymphocyte function bronchial asthma Part 1. Examination of lymphocyte responsiveness with inhalation antigens of bronchial asthma

Takada, Sho
103_387.pdf 3.52 MB
Published Date
1991
Abstract
Various antigens such as mite and fungi have been known to provoke bronchoconstriction in patients with bronchial asthma. The allergic mechanisms of asthmatic attack induced by these antigens were analyzed to clarify the role of cellular immunity in the pathogenesis of bronchial asthma. Mite and Candida antigens were applied to lymphocyte blastogenesis in asthmatic patients. Both lymphocytes in bronchoalveolar lavage fluid (BALF) and in peripheral blood of asthmatic patients responded significantly to mite and Candida antiten. Furthermore, BALF lymphocytes of patients with non-atopic and intractable asthma showed higher responses against Candida antigen than those of patients with atopic and non-intractable asthma, while peripheral blood lymphocytes showed a higher response against mite antigen in patients with atopic and non-intractable asthma. These findings indicate that lymphocytes in lugns sensitized with Candida antigen might play an important role in the pathogenesis of non-atopic and intractable asthma.
Keywords
気管支喘息
リンパ球幼若化反応
bronchoalveolar lavage
Candida
mite
Note
原著
ISSN
0030-1558
NCID
AN00032489