A 60-year-old man was diagnosed as having progressive supranuclear palsy on the basis of his clinical symptoms of disturbance of balance and gait with unexpected falls, masking of the face, reduction is the volume of the voice and ophthalmoplegia. I-123 IMP, Tc-99m PAO SPECT and CT were performed. The CT examination showed atrophy of the midbrain, inter-brain and pons. SPECT studies revealed severe hypoperfusion bilaterally in the frontal cortex. These SPECT findings correspond to the report of frontal cortex hypometabolism detected by position tomography in patients with progressive supranuclear palsy (Brain 1985, 108, 785-799).