Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

培養血管平滑筋細胞における脂質代謝に関する研究 第1編 細胞増殖と過酸化脂質生成に及ぼす抗酸化剤の影響について

Demiya, Michitaka
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Abstract
The effects of antioxidants on cell proliferation and lipid peroxide formation of cultured aortic smooth muscle cells obtained from normal, hypercholesterolemic and aged rabbits were studied in vitro.α-Tocopherol and coenzyme Q(10) were used as antioxidants.The lipid peroxide content of cells was generated in a time dependent manner with cell proliferation, it remained within the cells and did not accumulate in the media.α-Tocopherol promoted cell proliferation and suppressed the intracellular lipid peroxide formation expressed in terms of DNA content.These effects were significant only in HL-SMC, and were not significant in NR-SMC or Aged-SMC. Coenzyme Q(10) did not effect cell proliferation or lipid peroxide formation.
Keywords
平滑筋細胞
過酸化脂質
α-トコフェロール
コエンザイムQ(10)
抗酸化剤
ISSN
0030-1558
NCID
AN00032489