The objective of this study was to identify work-related stress and lifestyle associated with multiple lifestyle-related diseases. Male workers aged 19-66 years (N=490) completed a self-reported questionnaire. Relationships between demographic variables, work-related stress variables, lifestyle variables and multiple lifestyle related diseases were investigated using regression analyses and path analyses. A best fit path model on multiple lifestyle-related diseases was constructed using eating behaviors as mediators. Age, education, binge eating and overeating were significantly associated with multiple lifestyle-related diseases in the direct paths. Depression and inflexible workplace climate were significantly associated with multiple lifestyle-related diseases in the indirect paths through the variables, binge eating and overeating. These findings suggest that workers' mental health and workplace climate, as well as unhealthy eating behaviors, may be important factors in preventing lifestyle-related diseases in male workers.