Acta Medica Okayama volume75 issue1
2021-02 発行

The Optimal Timing of Antiretroviral Therapy Initiation in HIV-Infected Patients with Cryptococcal Meningitis: A Multicenter Prospective Randomized Controlled Trial

Xu, Xiaolei Division of Infectious Diseases, Chongqing Public Health Medical Center
Lu, Yanqiu Division of Infectious Diseases, Chongqing Public Health Medical Center
Harypursat, Vijay Division of Infectious Diseases, Chongqing Public Health Medical Center
Sun, Feng Division of Infectious Diseases, Chongqing Public Health Medical Center
Zhao, Ting Division of Infectious Diseases, Chongqing Public Health Medical Center
Zeng, Yanming Division of Infectious Diseases, Chongqing Public Health Medical Center
He, Xiaoqing Division of Infectious Diseases, Chongqing Public Health Medical Center
Chen, Yaokai Division of Infectious Diseases, Chongqing Public Health Medical Center
Publication Date
2021-02
Abstract
The optimal timing of antiretroviral therapy (ART) initiation in human immunodeficiency virus (HIV)-infected patients with cryptococcal meningitis (HIV/CM) is controversial. We designed a clinical trial to inves-tigate the optimal timing for ART initiation in HIV/CM patients. This will be a multicenter, prospective, and randomized clinical trial. Each enrolled patient will be randomized into either the early ART arm or the deferred ART arm. We will compare the mortality and incident rates of immune reconstitution inflammatory syndrome between the two arms. We hope to elucidate the optimal timing for ART initiation in HIV/CM patients.
Document Type
Clinical Study Protocol
Keywords
human immunodeficiency virus
meningitis
cryptococcal
antiretroviral therapy
Link to PubMed
75_1_109.pdf 1.96 MB