Acta Medica Okayama volume74 issue6
2020-12 発行

A Japanese Patient with Gastric Cancer and Dihydropyrimidine Dehydrogenase Deficiency Presenting with DPYD Variants

Ishiguro, Mikako Department of Internal Medicine, Tsuyama Chuo Hospital
Takenaka, Ryuta Department of Internal Medicine, Tsuyama Chuo Hospital
Ogura, Kenichiro Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
Hiratsuka, Akira Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
Takeda, Hiromasa Department of Internal Medicine, Tsuyama Chuo Hospital
Kawai, Daisuke Department of Internal Medicine, Tsuyama Chuo Hospital
Tsugeno, Hirofumi Department of Internal Medicine, Tsuyama Chuo Hospital
Fujiki, Shigeatsu Department of Internal Medicine, Tsuyama Chuo Hospital
Okada, Hiroyuki Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap
Publication Date
2020-12
Abstract
A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydroge-nase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at posi-tions 1615 (G > A), 1627 (A > G), and 1896 (T > C) in exons 13, 13, and 14, respectively.
Document Type
Case Report
Keywords
5-fluorouracil
dihydropyrimidine dehydrogenase deficiency
DPYD variant
gastric cancer
Link to PubMed