Acta Medica Okayama volume74 issue4
2020-08 発行

Relationship Between Partial Carbon Dioxide Pressure and Strong Ions in Humans: A Retrospective Study

Isoyama, Satoshi Department of Anesthesiology and Resuscitation, Okayama University Hospital
Kimura, Satoshi Department of Anesthesiology and Resuscitation, Okayama University Hospital
Morimatsu, Hiroshi Department of Anesthesiology and Resuscitation, Okayama University Hospital ORCID Kaken ID publons researchmap
Publication Date
2020-08
Abstract
Little is known about the role of a strong ions in humans with respiratory abnormalities. In this study, we investigated the associations between partial carbon dioxide pressure (pCO2) and each of sodium ion (Na+) concentrations, chloride ion (Cl−) concentrations and their difference (SIDNa-Cl). Blood gas data were obtained from patients in a teaching hospital intensive care unit between August 2013 and January 2017. The association between pCO2 and SIDNa-Cl was defined as the primary outcome. The associations between pCO2 and [Cl−], [Na+] and other strong ions were secondary outcomes. pCO2 was stratified into 10 mmHg-wide bands and treated as a categorical variable for comparison. As a result, we reviewed 115,936 blood gas data points from 3,840 different ICU stays. There were significant differences in SIDNa-Cl, [Cl−], and [Na+] among all categorized pCO2 bands. The respective pCO2 SIDNa-Cl, [Cl−], and [Na+] correlation coefficients were 0.48, −0.31, and 0.08. SIDNa-Cl increased and [Cl−] decreased with pCO2, with little relationship between pCO2 and [Na+] across subsets. In conclusion, we found relatively strong correlations between pCO2 and SIDNa-Cl in the multiple blood gas datasets examined. Correlations between pCO2 and chloride concentrations, but not sodium concentrations, were further found to be moderate in these ICU data.
Document Type
Original Article
Keywords
acid-base phenomena
Stewart approach
strong ion difference
chlorine ion
partial carbon dioxide pressure
Link to PubMed