Acta Medica Okayama volume74 issue4
2020-08 発行

Preoperative Use of Alpha-1 Receptor Blockers in Male Patients Undergoing Extracorporeal Shock Wave Lithotripsy for a Ureteral Calculus

Yoshioka, Takashi Center for Innovative Research for Communities and Clinical Excellence (CiRC2LE), Fukushima Medical University
Omae, Kenji Center for Innovative Research for Communities and Clinical Excellence (CiRC2LE), Fukushima Medical University
Kawada, Tatsushi Department of Urology, Onomichi Municipal Hospital
Inoue, Yosuke Department of Urology, Onomichi Municipal Hospital
Sugimoto, Morito Department of Urology, Onomichi Municipal Hospital
Oeda, Tadashi Department of Urology, Onomichi Municipal Hospital
Uehara, Shinya Department of Urology, Kawasaki Medical School General Medical Center
Araki, Motoo Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Fukuhara, Shunichi Center for Innovative Research for Communities and Clinical Excellence (CiRC2LE), Fukushima Medical University
Publication Date
2020-08
Abstract
In this retrospective single-center cohort study, we investigated the impact of preoperative use of an alpha-1 adrenergic receptor (AR) blocker on the outcome of single-session extracorporeal shock wave lithotripsy (SWL) in 193 male patients who underwent SWL for a single ureteral calculus between 2006 and 2016. We reviewed their medical records to obtain the data on the preoperative use of alpha-1 AR blockers. The primary outcome was treatment success after single-session SWL. We performed a multivariable logistic regression analysis adjusting for clinically important confounders to examine the association between preoperative use of alpha-1 AR blockers and the treatment success of SWL. Among the 193 patients, 15 (7.8%) were taking an alpha-1 AR blocker preoperatively. A multivariable analysis showed that preoperative use of an alpha-1 AR blocker was a significant negative predictor for treatment success of SWL (adjusted odds ratio 0.17; 95% confidence intervals, 0.04-0.74). Our findings suggest that the preoperative use of an alpha-1 AR blocker was a negative predictor of treatment success of SWL in male patients with a single ureteral calculus. Clinicians should pay more attention to the preoperative drug use in determining an appropriate stone therapy modality.
Document Type
Original Article
Keywords
urolithiasis
extracorporeal shockwave therapy
adrenergic alpha-1 receptor antagonists
Link to PubMed
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