Acta Medica Okayama volume74 issue3
2020-06 発行

A Randomized Phase 2 Trial of Antibiotic Prophylaxis Versus No Intervention for Muscle Biopsy in A Neurology Department

Nakahara, Keiichi Department of Neurology, Graduate School of Medical Sciences, Kumamoto University
Ikeda, Tokunori Department of Clinical Investigation, Kumamoto University Hospital
Takamatsu, Koutaro Department of Neurology, Graduate School of Medical Sciences, Kumamoto University
Tawara, Nozomu Department of Neurology, Graduate School of Medical Sciences, Kumamoto University
Hara, Kentaro Department of Neurology, Graduate School of Medical Sciences, Kumamoto University
Enokida, Yuki Department of Pharmacy, Kumamoto University Hospital
Tanoue, Naomi Department of Pharmacy, Kumamoto University Hospital
Narita, Sawana Department of Clinical Investigation, Kumamoto University Hospital
Fujii, Akiko Department of Clinical Investigation, Kumamoto University Hospital
Yamanouchi, Yoshinori Department of Clinical Investigation, Kumamoto University Hospital
Morinaga, Jun Department of Clinical Investigation, Kumamoto University Hospital
Yamashita, Satoshi Department of Neurology, Graduate School of Medical Sciences, Kumamoto University
Publication Date
2020-06
Abstract
Muscle biopsy can be used to confirm the diagnosis of neuromuscular diseases. However, it is unclear whether antibiotic prophylaxis prior to muscle biopsy is needed to prevent surgical site infection (SSI). We are conducting a phase 2, single-center, open-labeled, prospective randomized trial to clarify the need for antibiotic prophylaxis in patients at low risk for SSI undergoing muscle biopsy. Patients will be randomized to an antibiotic prophylaxis group or a control group, and the incidence of SSI will be compared between the groups. Our findings will clarify the need for antibiotic prophylaxis in this patient population.
Document Type
Clinical Study Protocol
Keywords
muscle biopsy
antibiotic prophylaxis
Link to PubMed
Thumnail 74_3_261.pdf 1.87 MB