Acta Medica Okayama volume74 issue3
2020-06 発行

Stem Cell Therapy in Heart Disease: Limitations and Future Possibilities

Sano, Toshikazu Department of Surgery, Division of Pediatric Cardiothoracic Surgery, University of California San Francisco
Ishigami, Shuta Department of Surgery, Division of Pediatric Cardiothoracic Surgery, University of California San Francisco
Ito, Tatsuo Department of Hygiene, Kawasaki Medical University
Sano, Shunji Department of Surgery, Division of Pediatric Cardiothoracic Surgery, University of California San Francisco
Publication Date
2020-06
Abstract
Heart diseases are one of the major causes of morbidity and mortality worldwide. Despite major advances in drug and interventional therapies, surgical procedures, and organ transplantation, further research into new therapeutic options is still necessary. Stem cell therapy has emerged as one option for the treatment of a variety of heart diseases. Although a large number of clinical trials have shown stem cell therapy to be a promising therapeutic approach, the results obtained from these clinical studies are inconsistent, and stem cell-based improvements of heart performance and cardiac remodeling were found to be quite limited. Since the precise mechanisms underlying the therapeutic actions of stem cells are still under debate, researchers have developed a variety of strategies to improve and boost the potency of stem cells in repair. In this review, we summarize both the current therapeutic strategies using stem cells and future directions for enhancing stem cell potency.
Document Type
Review
Keywords
heart disease
stem cell
myocardial regeneration
Link to PubMed