Acta Medica Okayama volume74 issue2
2020-04 発行

Juvenile Granulosa Cell Tumor with an Unusual Clinical Course: A Late-onset and Late Recurrent Case

Thar Htet San Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ota, Yoko Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Fushimi, Soichiro Department of Pathology, Himeji Red Cross Hospital
Fujisawa, Masayoshi Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Yanai, Hiroyuki Department of Pathology, Okayama University Hospital
Toda, Hiroko Section of Diagnostic Pathology, Fukuyama Medical Association
Kunitomo, Tadayoshi Department of Pathology, Kurashiki Medical Center
Kodama, Keisuke Department of Gynecology, Kurashiki Medical Center
Matsukawa, Akihiro Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID researchmap
Publication Date
2020-04
Abstract
Juvenile granulosa cell tumors (JGCTs) are rare ovarian tumors with overall good prognoses. They differ from adult granulosa cell tumors (AGCTs), which are well known for late recurrence. Most JGCTs (~97%) occur in individuals <30 years old. We report a recurrent JGCT in a 40-year-old woman 5 years after initial presentation. The histological appearance and lack of 402C>G missense point mutation of FOXL2 gene (characteristic of AGCT but absent in JGCT) allowed differentiation from AGCT. This is the first comprehensive report of JGCT with late recurrence. Although rare, late recurrence of JGCT can occur; long-term surveillance is suggested.
Document Type
Case Report
Keywords
juvenile granulosa cell tumor
late recurrence
adult granulosa cell tumor
Link to PubMed