Acta Medica Okayama volume73 issue5
2019-10 発行

The Role of High Mobility Group Box-1 in Epileptogenesis

Fu, Li Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Nishibori, Masahiro Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Publication Date
2019-10
Abstract
High mobility group box-1 (HMGB1) is a non-histone, DNA-binding nuclear protein belonging to the family of damage-associated molecular patterns (DAMPs). HMGB1 has been reported to play an important role during epileptogenesis although the mechanisms of its actions are still not clear. Many hypotheses have been suggested especially about the relationship between HMGB1 and inflammation responses and blood-brain barrier disruption during epileptogenesis. In this review, we will mainly discuss the role of HMGB1 in epileptogenesis.
Document Type
Review
Keywords
HMGB1
epileptogenesis
inflammation
blood-brain barrier
Link to PubMed
Thumnail 73_5_383.pdf 1.84 MB