Acta Medica Okayama volume73 issue5
2019-10 発行

Histidine-rich Glycoprotein Modulates the Blood-vascular System in Septic Condition

Wake, Hidenori Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Publication Date
2019-10
Abstract
Histidine-rich glycoprotein (HRG) is a 75 kDa glycoprotein synthesized in the liver whose plasma concentration is 100-150 μg/ml. HRG has been shown to modulate sepsis-related biological reactions by binding to several substances and cells, including heparin, factor XII, fibrinogen, thrombospondin, plasminogen, C1q, IgG, heme, LPS, dead cells, bacteria, and fungi. Therefore, reduction of plasma HRG levels in sepsis leads to dysregulation of coagulation, fibrinolysis, and immune response, resulting in disseminated intravascular coagulation and multiple organ failure. This review summarizes the binding and functional properties of HRG in sepsis.
Document Type
Review
Keywords
htidine-rich glycoprotein
septic pathogenesis
immunothrombosis
Link to PubMed
Thumnail 73_5_379.pdf 1.96 MB