Acta Medica Okayama volume73 issue1
2019-02 発行

Histidine-rich Glycoprotein Could Be an Early Predictor of Vasospasm after Aneurysmal Subarachnoid Hemorrhage

Matsumoto, Atsushi Department of Neurological Surgery, Kagawa University Faculty of Medicine
Nakamura, Takehiro Department of Medical Technology, Kagawa Prefectural University of Health Sciences
Shinomiya, Aya Department of Neurological Surgery, Kagawa University Faculty of Medicine
Kawakita, Kenya Emergency Medical Center, Kagawa University Hospital
Kawanishi, Masahiko Department of Neurological Surgery, Kagawa University Faculty of Medicine
Miyake, Keisuke Department of Neurological Surgery, Kagawa University Faculty of Medicine
Kuroda, Yasuhiro Emergency Medical Center, Kagawa University Hospital
Keep, Richard F. Department of Neurosurgery, University of Michigan
Tamiya, Takashi Department of Neurological Surgery, Kagawa University Faculty of Medicine
Publication Date
2019-02
Abstract
Cerebral vasospasm (CVS) is a major contributor to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. We measured histidine-rich glycoprotein (HRG), a new biomarker of aSAH, in cerebrospinal fluid (CSF) to investigate whether HRG might be an early predictor of CVS. A total of seven controls and 14 aSAH patients (8 males, 6 females aged 53.4±15.4 years) were enrolled, and serial CSF and serum samples were taken. We allocated these samples to three phases (T1-T3) and measured HRG, interleukin (IL)-6, fibrinopeptide A (FpA), and 8-hydroxy-2’-deoxyguanosine (8OHdG) in the CSF, and the HRG in serum. We also examined the release of HRG in rat blood incubated in artificial CSF. In contrast to the other biomarkers examined, the change in the CSF HRG concentration was significantly different between the nonspasm and spasm groups (p<0.01). The rat blood/CSF model revealed a time course similar to that of the human CSF samples in the non-spasm group. HRG thus appears to have the potential to become an early predictor of CVS. In addition, the interaction of HRG with IL-6, FpA, and 8OHdG may form the pathology of CVS.
Document Type
Original Article
Keywords
biomarker
histidine-rich glycoprotein
predictor
subarachnoid hemorrhage
vasospasm
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