Acta Medica Okayama volume71 issue1
2017-02 発行

Effects of Therapeutic Hypothermia for Neuroprotection from the Viewpoint of Redox Regulation

Nosaka, Nobuyuki Department of Pediatrics, Okayama University School of Medicine, Dentistry and Pharmaceutical Sciences
Okada, Ayumi Department of Pediatrics, Okayama University School of Medicine, Dentistry and Pharmaceutical Sciences
Tsukahara, Hirokazu Department of Pediatrics, Okayama University School of Medicine, Dentistry and Pharmaceutical Sciences
Publication Date
2017-02
Abstract
Redox regulation has recently been recognized as an important factor in acute illnesses as well as in chronic diseases. It has also become a target for neuroprotection in acute intensive care. Despite its well-known therapeutic effects, therapeutic hypothermia has recently been re-evaluated for its potential use in emergency and critical care medicine. Hypothermia is an undesirable physiological condition that can increase oxidative stress and decrease anti-oxidative potency. However, many studies have shown that under ischemia/reperfusion conditions, therapeutic hypothermia actually suppresses enhanced oxidative stress and maintains or increases anti-oxidative potency. This review provides an overview and outlook for the future of therapeutic hypothermia for neuroprotection from the perspective of redox regulation in patients with post-cardiac arrest syndrome and traumatic brain injury.
Document Type
Review
Keywords
post-cardiac arrest syndrome
traumatic brain injury
therapeutic hypothermia
oxidative stress
intensive care
Link to PubMed
Thumnail 71_1_1.pdf 2.21 MB