In this paper, a new rule induction method by using EDA with instance-subpopulations is proposed. The proposed method introduces a notion of instance-subpopulation, where a set of individuals matching a training instance. Then, EDA procedure is separately carried out for each instance-subpopulation. Individuals generated by each EDA procedure are merged to constitute the population at the next generation. We examined the proposed method on Breast-cancer in Wisconsin and Chess End-Game. The comparisons with other algorithms show the effectiveness of the proposed method.