ID 60878
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Author
Hoffmann, Jan, V Department of Nuclear Medicine, University Hospital Würzburg
Janssen, Jan P. Department of Nuclear Medicine, University Hospital Würzburg
Kanno, Takayuki Comprehensive Heart Failure Center, University Hospital Würzburg
Shibutani, Takayuki Department of Quantum Medical Technology, Graduate School of Medical Sciences
Onoguchi, Masahisa Department of Quantum Medical Technology, Graduate School of Medical Sciences
Lapa, Constantin Nuclear Medicine, Medical Faculty, University of Augsburg
Grunz, Jan-Peter Department of Diagnostic and Interventional Radiology, University Hospital Würzburg
Buck, Andreas K. Department of Nuclear Medicine, University Hospital Würzburg
Higuchi, Takahiro Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University ORCID Kaken ID publons researchmap
Abstract
Background Small-animal single-photon emission computed tomography (SPECT) systems with multi-pinhole collimation and large stationary detectors have advantages compared to systems with moving small detectors. These systems benefit from less labour-intensive maintenance and quality control as fewer prone parts are moving, higher accuracy for focused scans and maintaining high resolution with increased sensitivity due to focused pinholes on the field of view. This study aims to investigate the performance of a novel ultra-high-resolution scanner with two-detector configuration (U-SPECT5-E) and to compare its image quality to a conventional micro-SPECT system with three stationary detectors (U-SPECT+). Methods The new U-SPECT5-E with two stationary detectors was used for acquiring data with Tc-99m-filled point source, hot-rod and uniformity phantoms to analyse sensitivity, spatial resolution, uniformity and contrast-to-noise ratio (CNR). Three dedicated multi-pinhole mouse collimators with 75 pinholes each and 0.25-, 0.60- and 1.00-mm pinholes for extra ultra-high resolution (XUHR-M), general-purpose (GP-M) and ultra-high sensitivity (UHS-M) imaging were examined. For CNR analysis, four different activity ranges representing low- and high-count settings were investigated for all three collimators. The experiments for the performance assessment were repeated with the same GP-M collimator in the three-detector U-SPECT+ for comparison. Results Peak sensitivity was 237 cps/MBq (XUHR-M), 847 cps/MBq (GP-M), 2054 cps/MBq (UHS-M) for U-SPECT5-E and 1710 cps/MBq (GP-M) for U-SPECT+. In the visually analysed sections of the reconstructed mini Derenzo phantoms, rods as small as 0.35 mm (XUHR-M), 0.50 mm (GP-M) for the two-detector as well as the three-detector SPECT and 0.75 mm (UHS-M) were resolved. Uniformity for maximum resolution recorded 40.7% (XUHR-M), 29.1% (GP-M, U-SPECT5-E), 16.3% (GP-M, U-SPECT+) and 23.0% (UHS-M), respectively. UHS-M reached highest CNR values for low-count images; for rods smaller than 0.45 mm, acceptable CNR was only achieved by XUHR-M. GP-M was superior for imaging rods sized from 0.60 to 1.50 mm for intermediate activity concentrations. U-SPECT5-E and U-SPECT+ both provided comparable CNR. Conclusions While uniformity and sensitivity are negatively affected by the absence of a third detector, the investigated U-SPECT5-E system with two stationary detectors delivers excellent spatial resolution and CNR comparable to the performance of an established three-detector-setup.
Keywords
Small-animal imaging
SPECT
Mouse
Collimator
Post-reconstruction filtering
Published Date
2020-11-02
Publication Title
EJNMMI Physics
Volume
volume7
Issue
issue1
Publisher
Springer
Start Page
64
ISSN
2197-7364
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© The Author(s). 2020
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Related Url
isVersionOf https://doi.org/10.1186/s40658-020-00335-6
License
http://creativecommons.org/licenses/by/4.0/