ID 60289
Author
Yamamoto, Hiromasa Department of Thoracic Surgery, Okayama University Hospital ORCID Kaken ID researchmap
Namba, Kei Department of Thoracic Surgery, Okayama University Hospital
Yamamoto, Haruchika Department of Thoracic Surgery, Okayama University Hospital
Toji, Tomohiro Department of Diagnostic Pathology, Okayama University Hospital
Soh, Junichi Department of Thoracic Surgery, Okayama University Hospital
Shien, Kazuhiko Department of Thoracic Surgery, Okayama University Hospital ORCID Kaken ID researchmap
Suzawa, Ken Department of Thoracic Surgery, Okayama University Hospital
Kurosaki, Takeshi Department of Thoracic Surgery, Okayama University Hospital Kaken ID
Otani, Shinji Department of Thoracic Surgery, Okayama University Hospital
Okazaki, Mikio Department of Thoracic Surgery, Okayama University Hospital
Sugimoto, Seiichiro Department of Thoracic Surgery, Okayama University Hospital ORCID Kaken ID
Yamane, Masaomi Department of Thoracic Surgery, Okayama University Hospital Kaken ID researchmap
Takahashi, Katsuhito Center for Multidisciplinary Treatment of Sarcoma, Department of Sarcoma Medicine, Kameda Medical Center
Kunisada, Toshiyuki Department of Orthopedic Surgery, Okayama University Hospital Kaken ID researchmap
Oto, Takahiro Department of Thoracic Surgery, Okayama University Hospital Kaken ID publons
Toyooka, Shinichi Department of Thoracic Surgery, Okayama University Hospital ORCID Kaken ID publons researchmap
Abstract
Purpose
Sarcomas are among the most refractory malignant tumors and often recur as pulmonary metastasis. Although the presence of a high neutrophil-to-lymphocyte ratio (NLR) has been associated with the prognosis of several malignancies, the relationship between the NLR and sarcoma with pulmonary metastasis is unclear. We investigated the impact of the NLR in patients who underwent surgical resection for metastatic lung tumors from various sarcomas.
Methods
The subjects of this retrospective study were 158 patients with metastatic lung tumors from various sarcomas, who underwent initial pulmonary metastasectomy between 2006 and 2015. We examined the clinicopathological variables, including the NLR and the characteristics of surgical procedures. Survival was estimated by the Kaplan–Meier method and prognostic factors were evaluated by multivariate analysis.
Results
Multivariate analysis revealed significantly better survival of the group with an NLR < 2.26 immediately before the most recent pulmonary metastasectomy, in addition to such factors as the largest resected lesion being < 22 mm, a disease-free interval of > 2 years, and 3 or more pulmonary metastasectomies.
Conclusion
The NLR immediately before the most recent pulmonary metastasectomy is a novel independent prognostic factor, which may be helpful when considering repeated pulmonary metastasectomy.
Keywords
Metastatic lung tumor
Sarcoma
Metastasectomy
Survival rate
Neutrophil-to-lymphocyte ratio (NLR)
Note
This is a post-peer-review, pre-copyedit version of an article published in Surgery Today. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00595-020-02093-5.
This fulltext is available in Aug. 2021.
Published Date
2020-08-03
Publication Title
Surgery Today
Publisher
Springer
ISSN
0941-1291
NCID
AA10824685
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
File Version
author
PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1007/s00595-020-02093-5