ID 59978
Author
Iwamoto, Takayuki Department of Breast and Endocrine Surgery, Okayama University Hospital Kaken ID researchmap
Hara, Fumikata Breast Medical Oncology Department, Cancer Institute Hospital of JFCR
Uemura, Yukari Department of Clinical Research, National Center for Global Health and Medicine
Mukai, Hirofumi Department of Breast and Medical Oncology, National Cancer Center Hospital
Watanabe, Toru Department of Medical Oncology, Hamamatsu Oncology Center
Ohashi, Yasuo Department of Integrated Science and Engineering for Sustainable Society, Chuo University
Abstract
Background
Chemotherapy-induced amenorrhea (CIA) is one of the critical side effects from the chemotherapy in premenopausal patients with breast cancer. The goals of our study are the following: (1) to investigate the factors affecting the incidence of CIA; and (2) to evaluate the prognostic role of CIA in premenopausal patients with breast cancer.
Methods
We conducted a post hoc retrospective substudy to examine the incidence of the CIA and the relationship between CIA and prognosis in NSAS-BC02 that compared taxane alone to Doxorubicin(A) Cyclophosphamide(C) followed by taxane in postoperative patients with node-positive breast cancer
Results
Of 395 premenopausal women, 287 (72.7%) had CIA due to protocol treatment. Regarding type of protocol regimen, proportion of CIA was 76.9% in AC Paclitaxel(P), 75.2% in AC Docetaxel(D), 62.8% in PTX, and 75.2% in DTX. Predictive factors of CIA were age increase by 5 years (OR 1.50), ER positivity (OR 2.08), and HER2 3 + ( OR 0.40) according to logistic regression analysis. According to the log rank test and the Cox proportional hazards model, CIA group had significantly better disease-free survival than non-CIA group (P < .0001). However, according to time-dependent Cox model that was used to reduce guarantee-time bias, CIA was not a statistically significant prognostic factor in both ER-positive and ER-negative patients.
Conclusion
Treatment with taxane alone caused high frequency of CIA in premenopausal women with breast cancer. CIA did not turn out to be an independent prognostic factor, taking guarantee-time bias into consideration. Further clinical studies are needed to validate these findings.
Keywords
Chemotherapy-induced amenorrhea
Taxane
Taxane
Breast cancer
Guarantee-time bias
Premenopause
Note
This fulltext is available in May 2021.
Published Date
2020-05-28
Publication Title
Breast Cancer Research and Treatment
Volume
volume182
Issue
issue2
Publisher
Springer
Start Page
325
End Page
332
ISSN
0167-6806
NCID
AA10623184
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
File Version
author
PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1007/s10549-020-05692-5