ID 56456
JaLCDOI
FullText URL
Thumnail 73_1_29.pdf 2.8 MB
Author
Matsumoto, Atsushi Department of Neurological Surgery, Kagawa University Faculty of Medicine
Nakamura, Takehiro Department of Medical Technology, Kagawa Prefectural University of Health Sciences
Shinomiya, Aya Department of Neurological Surgery, Kagawa University Faculty of Medicine
Kawakita, Kenya Emergency Medical Center, Kagawa University Hospital
Kawanishi, Masahiko Department of Neurological Surgery, Kagawa University Faculty of Medicine
Miyake, Keisuke Department of Neurological Surgery, Kagawa University Faculty of Medicine
Kuroda, Yasuhiro Emergency Medical Center, Kagawa University Hospital
Keep, Richard F. Department of Neurosurgery, University of Michigan
Tamiya, Takashi Department of Neurological Surgery, Kagawa University Faculty of Medicine
Abstract
Cerebral vasospasm (CVS) is a major contributor to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. We measured histidine-rich glycoprotein (HRG), a new biomarker of aSAH, in cerebrospinal fluid (CSF) to investigate whether HRG might be an early predictor of CVS. A total of seven controls and 14 aSAH patients (8 males, 6 females aged 53.4±15.4 years) were enrolled, and serial CSF and serum samples were taken. We allocated these samples to three phases (T1-T3) and measured HRG, interleukin (IL)-6, fibrinopeptide A (FpA), and 8-hydroxy-2’-deoxyguanosine (8OHdG) in the CSF, and the HRG in serum. We also examined the release of HRG in rat blood incubated in artificial CSF. In contrast to the other biomarkers examined, the change in the CSF HRG concentration was significantly different between the nonspasm and spasm groups (p<0.01). The rat blood/CSF model revealed a time course similar to that of the human CSF samples in the non-spasm group. HRG thus appears to have the potential to become an early predictor of CVS. In addition, the interaction of HRG with IL-6, FpA, and 8OHdG may form the pathology of CVS.
Keywords
biomarker
histidine-rich glycoprotein
predictor
subarachnoid hemorrhage
vasospasm
Amo Type
Original Article
Published Date
2019-02
Publication Title
Acta Medica Okayama
Volume
volume73
Issue
issue1
Publisher
Okayama University Medical School
Start Page
29
End Page
39
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2019 by Okayama University Medical School
File Version
publisher
Refereed
True