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Author
Kanamitsu, Kiichiro Department of Pediatrics, Okayama University Hospital
Chayama, Kousuke Department of Pediatrics, Toyonaka Municipal Hospital
Washio, Kana Department of Pediatrics, Okayama University Hospital
Yoshida, Ryuichi Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Umeda, Yuzo Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Yagi, Takahito Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Shimada, Akira Department of Pediatrics, Okayama University Hospital
Abstract
Hepatitis-associated aplastic anemia (HAAA) is an acquired bone marrow failure syndrome that develops after seronegative fulminant hepatitis. Abnormal cytotoxic T-cell activation with cytokine release is a possible pathophysiology. We present the case of a 16-month-old Japanese male who developed HAAA following living-donor liver transplantation for fulminant hepatitis. His aplastic anemia was successfully treated with immunosuppressive therapy. He had been administered tacrolimus for prophylaxis against hepatic allograft rejection. Ten years after the HAAA onset, the patient’s bone marrow was found to be slightly hypoplastic. Tacrolimus may be effective in controlling abnormal immune reactions that can cause recurrent impaired hematopoiesis.
Keywords
hepatitis-associated aplastic anemia
impaired hematopoiesis
liver transplantation
immunosuppressive therapy
abnormal immune reaction
Amo Type
Case Report
Published Date
2018-10
Publication Title
Acta Medica Okayama
Volume
volume72
Issue
issue5
Publisher
Okayama University Medical School
Start Page
515
End Page
518
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2018 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID