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Waki, Takahiro Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Katsui, Kuniaki Department of Radiology, Okayama University Hospital
Mitsuhashi, Toshiharu Center for Innovative Clinical Medicine, Okayama University Hospital
Ogata, Takeshi Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Katayama, Norihisa Department of Radiology, Okayama University Hospital
Takemoto, Mitsuhiro Department of Radiology, Japanese Red Cross Society Himeji Hospital
Nasu, Yasutomo Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kumon, Hiromi Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kanazawa, Susumu Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Abstract
We investigated differences in seminal vesicle (SV) length and interfractional SV motion relative to the prostate gland in prostate cancer patients. We compared 32 patients who received androgen deprivation therapy (ADT) before radiotherapy with 12 patients receiving radiotherapy alone at Okayama University Hospital in August 2008-July 2011. We examined the right and left SVs’ length and motion by computed tomography (CT) to determine the ADT’s effects and analyzed 347 CT scans in a multiple linear regression model. The ADT patients’ SV length was significantly shorter than the non-ADT patients’. The differences in right and left SV lengths between the ADT and non-ADT patients were 6.8 mm (95% CI 2.0-11.7 mm) and 7.2 mm (95% CI 3.1-11.3 mm) respectively in an adjusted regression model. SV motion did not differ between the ADT and non-ADT patients in terms of interfractional motion of the SV tips and the SVs’ center relative to the prostate gland. The ADT patients had significantly shorter SVs compared to the non-ADT patients, but no difference in SV motion was observed. SV interfractional motion should thus be compensated using the same planning margins, regardless of whether ADT is used.
Keywords
prostate cancer
androgen deprivation therapy
seminal vesicle length
seminal vesicle motion
imageguided radiotherapy
Published Date
2017-02
Publication Title
Acta Medica Okayama
Volume
volume71
Issue
issue1
Publisher
Okayama University Medical School
Start Page
31
End Page
39
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2017 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Amo Type
Original Article
Submission Path
amo/vol71/iss1/5
JaLCDOI