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ID 54819
FullText URL
Thumnail 71_1_1.pdf 2.21 MB
Author
Nosaka, Nobuyuki Department of Pediatrics, Okayama University School of Medicine, Dentistry and Pharmaceutical Sciences
Okada, Ayumi Department of Pediatrics, Okayama University School of Medicine, Dentistry and Pharmaceutical Sciences
Tsukahara, Hirokazu Department of Pediatrics, Okayama University School of Medicine, Dentistry and Pharmaceutical Sciences
Abstract
Redox regulation has recently been recognized as an important factor in acute illnesses as well as in chronic diseases. It has also become a target for neuroprotection in acute intensive care. Despite its well-known therapeutic effects, therapeutic hypothermia has recently been re-evaluated for its potential use in emergency and critical care medicine. Hypothermia is an undesirable physiological condition that can increase oxidative stress and decrease anti-oxidative potency. However, many studies have shown that under ischemia/reperfusion conditions, therapeutic hypothermia actually suppresses enhanced oxidative stress and maintains or increases anti-oxidative potency. This review provides an overview and outlook for the future of therapeutic hypothermia for neuroprotection from the perspective of redox regulation in patients with post-cardiac arrest syndrome and traumatic brain injury.
Keywords
post-cardiac arrest syndrome
traumatic brain injury
therapeutic hypothermia
oxidative stress
intensive care
Published Date
2017-02
Publication Title
Acta Medica Okayama
Volume
volume71
Issue
issue1
Publisher
Okayama University Medical School
Start Page
1
End Page
9
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2017 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Amo Type
Review
Submission Path
amo/vol71/iss1/1
JaLCDOI