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Maeda, Yoshinobu Department of Hematology and Oncology, Okayama University Hospital
Nishimori, Hisakazu Department of Hematology and Oncology, Okayama University Hospital
Inamoto, Yoshihiro Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital
Nakamae, Hirohisa Department of Hematology, Osaka City University Hospital
Sawa, Masashi Department of Hematology and Oncology, Anjo Kosei Hospital
Mori, Yasuo Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences
Ohashi, Kazuteru Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center
Fujiwara, Shin-ichiro Division of Hematology, Department of Medicine, Jichi Medical University
Tanimoto, Mitsune Department of Hematology and Oncology, Okayama University Hospital
Abstract
Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HSCT). Retinoic acid (tamibarotene) exerts multiple effects on cell differentiation and is clinically used for the treatment of acute promyelocytic leukemia. Tamibarotene down-regulates both Th1 and Th17 differentiation in donor T cells after allogeneic HSCT, resulting in attenuation of experimental chronic GVHD. Based on preclinical data, we have launched a phase II study of tamibarotene in patients with steroid-refractory chronic GVHD. This study will clarify whether tamibarotene can exert beneficial effects in patients with steroid-refractory chronic GVHD.
Keywords
Am80
tamibarotene
retinoid
chronic GVHD
steroid-refractory GVHD
Amo Type
Clinical Study Protocols
Published Date
2016-10
Publication Title
Acta Medica Okayama
Volume
volume70
Issue
issue5
Publisher
Okayama University Medical School
Start Page
409
End Page
412
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2016 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT