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Role of COLXV/XVⅢ gene, Multiplexin, as a basement membrane toolkit
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Okayama Medical Association
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Copyright (c) 2015 岡山医学会
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1) Hynes RO : The evolution of metazoan extracellular matrix. J Cell Biol (2012) 196, 671-679.
2) Yurchenco PD : Basement membranes : cell scaffoldings and signaling platforms. Cold Spring Harb Perspect Biol (2011) 3, pii : a004911.
3) Hutter H, Vogel BE, Plenefisch JD, Norris CR, Proenca RB, Spieth J, Guo C, Mastwal S, Zhu X, Scheel J, Hedgecock EM : Conservation and novelty in the evolution of cell adhesion and extracellular matrix genes. Science (2000) 287, 989-994.
4) Hynes RO, Zhao Q : The evolution of cell adhesion. J Cell Biol (2000) 150, F89-96.
5) Ackley BD, Crew JR, Elamaa H, Pihlajaniemi T, Kuo CJ, Kramer JM : The NC1/endostatin domain of Caenorhabditis elegans type XVIII collagen affects cell migration and axon guidance. J Cell Biol (2001) 152, 1219-1232.
6) Meyer and Moussian : Drosophila multiplexin (Dmp) modulates motor axon pathfinding accuracy. Dev Growth Differ (2009) 51, 483-498.
7) Momota R, Naito I, Ninomiya Y, Ohtsuka A : Drosophila type XV/XVIII collagen, Mp, is involved in Wingless distribution. Matrix Biol (2011) 30, 258-266.
8) Whittaker CA, Bergeron KF, Whittle J, Brandhorst BP, Burke RD, Hynes RO : The echinoderm adhesome. Dev Biol (2006) 300, 252-266.
9) Abe N, Muragaki Y, Yoshioka H, Inoue H, Ninomiya Y : Identification of a novel collagen chain represented by extensive interruptions in the triple-helical region. Biochem Biophys Res Commun (1993) 196, 576-582.
10) Oh SP, Kamagata Y, Muragaki Y, Timmons S, Ooshima A, Olsen BR : Isolation and sequencing of cDNAs for proteins with multiple domains of Gly-Xaa-Yaa repeats identify a distinct family of collagenous proteins. Proc Natl Acad Sci U S A (1994) 91, 4229-4233.
11) Muragaki Y, Abe N, Ninomiya Y, Olsen BR, Ooshima A : The human alpha 1 (XV) collagen chain contains a large amino-terminal non-triple helical domain with a tandem repeat structure and homology to alpha 1 (XVIII) collagen. J Biol Chem (1994) 269, 4042-4046.
12) Rehn M, Pihlajaniemi T : Alpha 1 (XVIII), a collagen chain with frequent interruptions in the collagenous sequence, a distinct tissue distribution, and homology with type XV collagen. Proc Natl Acad Sci U S A (1994) 91, 4234-4238.
13) Tomono Y, Naito I, Ando K, Yonezawa T, Sado Y, Hirakawa S, Arata J, Okigaki T, Ninomiya Y : Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are expressed in specialized basement membranes. Cell Struct Funct (2002) 27, 9-20.
14) Muragaki Y, Timmons S, Griffith CM, Oh SP, Fadel B, Quertermous T, Olsen BR : Mouse Col18a1 is expressed in a tissue-specific manner as three alternative variants and is localized in basement membrane zones. Proc Natl Acad Sci U S A (1995) 92, 8763-8767.
15) Rehn M, Pihlajaniemi T : Identification of three N-terminal ends of type XVIII collagen chains and tissue-specific differences in the expression of the corresponding transcripts. The longest form contains a novel motif homologous to rat and Drosophila frizzled proteins. J Biol Chem (1995) 270, 4705-4711.
16) Fukai N, Eklund L, Marneros AG, Oh SP, Keene DR, Tamarkin L, Niemelä M, Ilves M, Li E, Pihlajaniemi T, Olsen BR : Lack of collagen XVIII/endostatin results in eye abnormalities. EMBO J (2002) 21, 1535-1544.
17) Halfter W, Dong S, Schurer B, Cole GJ : Collagen XVIII is a basement membrane heparan sulfate proteoglycan. J Biol Chem (1998) 273, 25404-25412.
18) Li D, Clark CC, Myers JC : Basement membrane zone type XV collagen is a disulfide-bonded chondroitin sulfate proteoglycan in human tissues and cultured cells. J Biol Chem (2000) 275, 22339-22347.
19) Seppinen L, Pihlajaniemi T : The multiple functions of collagen XVIII in development and disease. Matrix Biol (2011) 30, 83-92.
20) Liétard J, Théret N, Rehn M, Musso O, Dargère D, Pihlajaniemi T, Clément B : The promoter of the long variant of collagen XVIII, the precursor of endostatin, contains liver-specific regulatory elements. Hepatology (2000) 32, 1377-1385.
21) Saarela J, Rehn M, Oikarinen A, Autio-Harmainen H, Pihlajaniemi T : The short and long forms of type XVIII collagen show clear tissue specificities in their expression and location in basement membrane zones in humans. Am J Pathol (1998) 153, 611-626.
22) Ylikärppä R, Eklund L, Sormunen R, Kontiola AI, Utriainen A, Määttä M, Fukai N, Olsen BR, Pihlajaniemi T : Lack of type XVIII collagen results in anterior ocular defects. FASEB J (2003) 17, 2257-2259.
23) Määttä M, Heljasvaara R, Pihlajaniemi T, Uusitalo M : Collagen XVIII/endostatin shows a ubiquitous distribution in human ocular tissues and endostatin-containing fragments accumulate in ocular fluid samples. Graefes Arch Clin Exp Ophthalmol (2007) 245, 74-81.
24) O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, Flynn E, Birkhead JR, Olsen BR, Folkman J : Endostatin : an endogenous inhibitor of angiogenesis and tumor growth. Cell (1997) 88, 277-285.
25) Hohenester E, Sasaki T, Olsen BR, Timpl R : Crystal structure of the angiogenesis inhibitor endostatin at 1.5 A resolution. EMBO J (1998) 17, 1656-1664.
26) Sasaki T, Larsson H, Kreuger J, Salmivirta M, Claesson-Welsh L, Lindahl U, Hohenester E, Timpl R : Structural basis and potential role of heparin/heparan sulfate binding to the angiogenesis inhibitor endostatin. EMBO J (1999) 18, 6240-6248.
27) Iozzo RV, Schaefer L : Proteoglycan form and function : A comprehends nomenclature of proteoglycans. Matrix Biol (2015) in press.
28) Marneros AG, Olsen BR : Physiological role of collagen XVIII and endostatin. FASEB J (2005) 19, 716-728.
29) Mongiat M, Sweeney SM, San Antonio JD, Fu J, Iozzo RV : Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan. J Biol Chem (2003) 278, 4238-4249.
30) Sasaki T, Fukai N, Mann K, Göhring W, Olsen BR, Timpl R : Structure, function and tissue forms of the C-terminal globular domain of collagen XVIII containing the angiogenesis inhibitor endostatin. EMBO J (1998) 17, 4249-4256.
31) Sertié AL, Sossi V, Camargo AA, Zatz M, Brahe C, Passos-Bueno MR : Collagen XVIII, containing an endogenous inhibitor of angiogenesis and tumor growth, plays a critical role in the maintenance of retinal structure and in neural tube closure (Knobloch syndrome). Hum Mol Genet (2000) 9, 2051-2058.
32) Suzuki OT, Sertié AL, Der Kaloustian VM, Kok F, Carpenter M, Murray J, Czeizel AE, Kliemann SE, Rosemberg S, Monteiro M, Olsen BR, Passos-Bueno MR : Molecular analysis of collagen XVIII reveals novel mutations, presence of a third isoform, and possible genetic heterogeneity in Knobloch syndrome. Am J Hum Genet (2002) 71, 1320-1329.
33) Fukai N, Eklund L, Marneros AG, Oh SP, Keene DR, Tamarkin L, Niemelä M, Ilves M, Li E, Pihlajaniemi T, Olsen BR : Lack of collagen XVIII/endostatin results in eye abnormalities. EMBO J (2002) 21, 1535-1544.
34) Ylikärppä R, Eklund L, Sormunen R, Kontiola AI, Utriainen A, Määttä M, Fukai N, Olsen BR, Pihlajaniemi T : Lack of type XVIII collagen results in anterior ocular defects. FASEB J (2003) 17, 2257-2259.
35) Moulton KS, Olsen BR, Sonn S, Fukai N, Zurakowski D, Zeng X : Loss of collagen XVIII enhances neovascularization and vascular permeability in atherosclerosis. Circulation (2004) 110, 1330-1336.
36) Kinnunen AI, Sormunen R, Elamaa H, Seppinen L, Miller RT, Ninomiya Y, Janmey PA, Pihlajaniemi T : Lack of collagen XVIII long isoforms affects kidney podocytes, whereas the short form is needed in the proximal tubular basement membrane. J Biol Chem (2011) 286, 7755-7764.
37) Zaferani A, Talsma DT, Yazdani S, Celie JW, Aikio M, Heljasvaara R, Navis GJ, Pihlajaniemi T, van den Born J : Basement membrane zone collagens XV and XVIII/proteoglycans mediate leukocyte influx in renal ischemia/reperfusion. PLoS One (2014) 9, e106732.
38) Eklund L, Piuhola J, Komulainen J, Sormunen R, Ongvarrasopone C, Fässler R, Muona A, Ilves M, Ruskoaho H, Takala TE, Pihlajaniemi T : Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice. Proc Natl Acad Sci U S A (2001) 98, 1194-1199.
39) Ackley BD, Kang SH, Crew JR, Suh C, Jin Y, Kramer JM : The basement membrane components nidogen and type XVIII collagen regulate organization of neuromuscular junctions in Caenorhabditis elegans. J Neurosci (2003) 23, 3577-3587.
40) Rasi K, Piuhola J, Czabanka M, Sormunen R, Ilves M, Leskinen H, Rysä J, Kerkelä R, Janmey P, Heljasvaara R, Peuhkurinen K, Vuolteenaho O, et al. : Collagen XV is necessary for modeling of the extracellular matrix and its deficiency predisposes to cardiomyopathy. Circ Res (2010) 107, 1241-1252.
41) Momota R, Narasaki M, Komiyama T, Naito I, Ninomiya Y, Ohtsuka A : Drosophila type XV/XVIII collagen mutants manifest integrin mediated mitochondrial dysfunction, which is improved by cyclosporin A and losartan. Int J Biochem Cell Biol (2013) 45, 1003-1011.