ID 53521
JaLCDOI
FullText URL
Thumnail 69_3_145.pdf 2.52 MB
Author
Ishii, Hiroko
Kamikawa, Shigeshi
Abstract
Eosinophil cationic protein (ECP) is well known as a cationic protein contained in the basic granules of activated eosinophils. Recent studies have reported that ECP exhibits novel activities on various types of cells, including rat neonatal cardiomyocytes. Here we evaluated the effects of ECP on rat cardiac myoblast H9c2 cells. Our results showed that ECP enhanced the survival of the cells, in part by promoting the ERK and Akt/GSK-3β signaling pathways. ECP attenuated the cytotoxic effects of H2O2 on H9c2 cells as well as the production of reactive oxygen species, the number of apoptotic cells and caspase 3/7 activity in the cells. In conclusion, ECP activated the ERK and Akt/GSK-3β pathways, resulting in anti-oxidative effects on H9c2 cells that attenuated apoptosis.
Keywords
ECP
reactive oxygen species
Akt
ERK
Amo Type
Original Article
Published Date
2015-06
Publication Title
Acta Medica Okayama
Volume
volume69
Issue
issue3
Publisher
Okayama University Medical School
Start Page
145
End Page
153
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2015 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT