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ID 52813
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Author
Sonoi, Norihiro
Ichimura, Koichi
Aoyama, Kazutoshi
Logan, Richard
Raber-Durlacher, Judith
Abstract
Here, we discuss the pathophysiology of leukemia-associated gingival enlargement based on a case of acute myelomonocytic leukemia (AML-M4) with typical gingival enlargement. Uniquely, this patient was well enough to allow full periodontal examination and incisional gingival biopsy to be performed both before and after chemotherapy. The patient was a 39-year-old Japanese woman with AML-M4 showing gingival enlargement. Histological and immunohistochemical features of gingiva and bacterial counts in the periodontal pockets were examined before and after chemotherapy. The results were as follows: (1) infiltration of myelomonocytic blasts in enlarged gingiva; (2) resolution of gingival enlargement with complete remission of AML by anticancer chemotherapy; and (3) the numbers of bacteria in the periodontal pockets were not high and were not altered before or after chemotherapy. In patients with AML-M4, remarkable mucosal enlargement is not generally observed in the body except in the gingiva. We hypothesized that antigens derived from periodontal bacteria, even if they are not present in large numbers, could act as chemoattractants for myelomonocytic leukemic cells.
Keywords
Gingival enlargement
Acute myelomonocytic leukemia
Pathogenesis
Histology
Immunohistochemistry
Note
The final publication is available at link.springer.com
Published Date
2012-07
Publication Title
Odontology
Volume
volume100
Issue
issue2
Start Page
254
End Page
257
ISSN
1618-1247
Content Type
Journal Article
language
英語
Copyright Holders
© The Society of The Nippon Dental University 2011
File Version
author
Refereed
True
DOI
Web of Sience KeyUT