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ID 52492
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Title Alternative
Behavioral analysis of the effects of long-term treatment with L-ornithine in mice
Author
Sogabe, Saki
Suzuki, Manami
Saiki, Akiko
Inoue, Rikako
Hayashi, Yasushi
Abstract
L-ornithine has recently received considerable attention as an anxiolytic-like or antifatigue agent in both human and animal studies. However, most previous results were obtained from a single administration of L-ornithine. Accordingly, this study was designed to clarify the effects of long-term L-ornithine treatment on psychological stress and locomotor activity in mice using a variety of behavioral pharmacology methods. In a stress-induced hyperthermia test, 10 days of L-ornithine treatment induced hyperthermia elevation. Pentobarbital-induced sleep time was shortened by the treatment. However, no significant effects were detected in the elevated plus-maze, running wheel, or forced swim tests. These results suggest that long-term treatment with L-ornithine elevates stress sensitivity and arousal level in mice.
Note
寄稿 (Contributions)
Published Date
2014-04
Publication Title
岡山実験動物研究会報
Publication Title Alternative
Proceedings of Okayama Association for Laboratory Animal Science
Volume
volume30
Publisher
岡山実験動物研究会
Publisher Alternative
Okayama Association for Laboratory Animal Science
Start Page
35
End Page
38
Content Type
Journal Article
language
日本語
File Version
publisher
Refereed
False
Eprints Journal Name
poalas