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ID 49112
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Author
Ishimaru, Fumihiko
Nishimura, Fusanori
Abstract
Coagulase-negative staphylococci (CoNS) are frequently isolated from blood cultures of hematopoietic cell transplantation (HCT) patients. Generally, the use of central venous catheters is recognized as a significant risk factor for CoNS infection, while the impact of CoNS infection from oral ulcerative mucositis, which occurs frequently in HCT, may be underestimated. Here, we examined the bacteria on the buccal mucosa after HCT. Sixty-one patients were examined for bacteria on the buccal mucosa routinely once a week from 1 week before to 3 weeks after allogeneic HCT. Subjects were divided into groups with short and long periods of antibiotic use, and differences in bacterial substitution were evaluated. The relationships between type of HCT (conventional HCT or RIST) and bacterial substitution were also evaluated. The changes in detection frequencies of CoNS and alpha-streptococci from before to 3 weeks after HCT were significant (P < 0.05, chi (2) test): 14.5-53.3% and 92.7-53.1%, respectively. Significant bacterial substitution of CoNS for streptococci was observed in the long-term antibiotic use group (P < 0.05, chi (2) test), but also occurred in cases with short-term or no antibiotic use. No relationships between type of HCT (conventional HCT or RIST) were observed. Bacterial substitution of CoNS for streptococci occurred frequently on the buccal mucosa after HCT. In addition to antibiotic use, environmental factors may be involved in bacterial substitution. It is important to consider the presence of oral mucositis in CoNS infection after HCT.
Keywords
Bacterial substitution
Oral mucosa
Hematopoietic cell transplantation
Coagulase-negative Staphylococcus
Bacteremia
Published Date
2011-07
Publication Title
Supportive Care in Cancer
Volume
volume19
Issue
issue7
Start Page
995
End Page
1000
ISSN
0941-4355
Content Type
Journal Article
Official Url
http://dx.doi.org/ 10.1007/s00520-010-0923-9
language
英語
File Version
author
Refereed
True
DOI
PubMed ID
Web of Sience KeyUT