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ID 48719
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Author
Nishiyama, Yuichi
Teraoka, Junichi
Sakoda, Akihiro
Ishimori, Yuu
Abstract
Radon inhalation activates antioxidative functions in some organs of mice. We examined the prevention effects of pre radon inhalation and the alleviation effects of post radon inhalation on carbon tetrachloride (CCl4)-induced oxidative damage in the brain, heart, lung, liver, and kidney of mice. In addition, we compared the effect of pre and post radon inhalation on oxidative damage. Mice inhaled radon at a concentration of 18000Bq/m3 for 6hrs before or after CCl4 administration. As a result, the total glutathione(t-GSH) contents and catalase(CAT) activities in the brain, heart, lung, liver, and kidney and superoxide dismutase(SOD) activities in the heart and lung were significantly higher in pre and post radon-inhaled mice than in mice treated with only CCl4. Pre radon inhalation inhibited and post radon inhalation reduced lipid peroxidation induced by CCl4. In addition, there were no significant differences in lipid peroxide(LPO) levels in the brain, heart, lung, liver, and kidney between pre and post radon-inhaled mice. These findings suggested that post radon inhalation has the same effects as pre radon inhalation against CCl4-induced oxidative damage in the brain, heart, lung, liver, and kidney.
Keywords
carbon tetrachloride
oxidative damage
pre or post radon inhalation
antioxidative function
Published Date
2012-05-29
Publication Title
RADIOISOTOPES
Volume
volume61
Issue
issue5
Publisher
Japan Radioisotope Association
Start Page
231
End Page
241
ISSN
0033-8303
NCID
AN00351589
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/radioisotopes/61/5/61_231/_article/
language
英語
Copyright Holders
Copyright © 2012 by Japan Radioisotope Association
File Version
publisher
Refereed
True
DOI